A MOLECULAR MAP OF LONG NON-CODING RNA EXPRESSION, ISOFORM SWITCHING AND ALTERNATIVE SPLICING IN OSTEOARTHRITIS

نویسندگان

چکیده

Purpose: Osteoarthritis is a prevalent degenerative joint disease with huge public health burden and no curative therapy. There clear urgent need to translate insights from genomics into better understanding of mechanisms. A hallmark osteoarthritis cartilage degradation. Here, we aim characterize molecular events in at the whole transcriptome level.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

SOX2OT, a long non-coding RNA involved in autophagy regulation

Summary: SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA associated with cancer pathogenesis. It contributes to a variety of cellular functions and recent evidence propounds its association with autophagy process. It has been showed that SOX2OT can regulate the expression of different autophagy associated factors in human cells with different mechanisms, however more remains to ...

متن کامل

Dysregulated Expression of Long Non-Coding RNA MINCR and EZH2 in Colorectal Cancer

Background: As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as EZH2. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known. Methods: In this study, the tissue expressions of lncRNA MINCR and EZH2 mRNA between colorect...

متن کامل

Evaluating the clinical importance of long-non coding RNA MALAT1 expression in breast cancer

Background: Breast cancer is one of the major causes of illness and mortality among women. Long non-coding RNAs (LncRNAs) have important role in tumor development and progression. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA that deregulates in several cancers, however, its value in the diagnosis of breast cancer is unclear. This study was conducted to investigate...

متن کامل

Correction: Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson’s Leukocytes Identified by RNA Sequencing

The images for Figures 2 and 3 are incorrectly switched. The image that appears as Figure 2 should be Figure 3, and the image that appears as Figure 3 should be Figure 2. The figure legends appear in the correct order. Copyright: ß 2014 The PLOS Computational Biology Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unre...

متن کامل

Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson's Leukocytes Identified by RNA Sequencing

The continuously prolonged human lifespan is accompanied by increase in neurodegenerative diseases incidence, calling for the development of inexpensive blood-based diagnostics. Analyzing blood cell transcripts by RNA-Seq is a robust means to identify novel biomarkers that rapidly becomes a commonplace. However, there is lack of tools to discover novel exons, junctions and splicing events and t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Osteoarthritis and Cartilage

سال: 2022

ISSN: ['1522-9653', '1063-4584']

DOI: https://doi.org/10.1016/j.joca.2022.02.473